Allergies are steadily increasing in industrialized countries. Nowadays, an allergy is defined as a specific hypersensitivity involving the immune system to substances which are actually harmless.
The four allergy types (type I – IV) originally classified by Coombs and Gell have meanwhile been joined by type V.
Type IV and V allergies
Type IV reactions are cellular reactions which predominantly involve T lymphocytes. The granulomatous type V allergy can be regarded as a variant of type IV allergy, as it also triggers a cell-mediated immune reaction, but involves macrophages instead of T lymphocytes.
As a rule, the allergens are proteins from natural sources such as pollens, animal epithelia, insect venoms, foodstuffs, mites etc., although medicines such as penicillin and its derivatives can also trigger type I allergies. Patients show often a wide range of varying symptoms and sensitization patterns against several allergens. It is necessary to test a patient’s blood whenever an allergic response or severe reaction is suspected. The allergy diagnostics of R-Biopharm AG offers two quantitative test methods for the antibody detection, the enzyme immunoassay (RIDASCREEN® Allergy ELISA) and the immunoblot (RIDA qLine® Allergy).
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