Intended use:

For in vitro diagnostic use. The RIDA®GENE Factor V kit uses real-time PCR to qualitatively detect a point mutation of G to A at position 1691 in the human factor V gene (Factor V Leiden mutation) in genomic DNA that was isolated from human EDTA whole blood samples.
The RIDA®GENE Factor V kit is intended to support the diagnosis in the assessment of patients with suspected thrombophilia.

General information:

Thromboses are a major medical problem that increases with age. Roughly 1 in 100,000 people under 40 years develop venous thrombosis. This probability increases in people over 75 years to 1 in 100 people per year. Factor V Leiden is considered the most common genetic factor that is described in combination with the development of venous thromboembolism. In this case, it is a point mutation in the factor V gene at position 1691 that leads to a base exchange from G to A. As a result, the binding site for activated protein C with anticoagulant effect is no longer available (APC resistance), and factor V is broken down less compared with the wild type, which results in a hypercoagulable state. Factor V Leiden is widely distributed with high prevalence in Europa and with practically no cases in Asia or Africa. The probability of developing venous thrombosis is 3 to 8 times higher with a genetic mutation in the factor V gene if this mutation is heterozygous. For a homozygous mutation at position 1691, the probability increases 10 to 80 times. In addition, the chance of developing venous thrombosis at a young age also increases in this case. If other factors, such as a mutation in the factor II gene (G20210A), are present with this mutation, the risk of recurrent thromboses increases as well.

Specifications
Art. No. PY1210
Test format real-time PCR with 100 reactions
Shelf life 24 months after production
Files
Instructions
SDS
sdspy1210_-_ridagene_factor_v_gb.pdf (English)
sdspy1210_-_ridagene_factor_v_de.pdf (German)
sdspy1210_-_ridagene_factor_v_fr.pdf (French)
sdspy1210_-_ridagene_factor_v_it.pdf (Italian)
sdspy1210_-_ridagene_factor_v_es.pdf (Spanish)
sdspy1210_-_ridagene_factor_v_bg.pdf (Bulgarian)
sdspy1210_-_ridagene_factor_v_cz.pdf (Czech)
sdspy1210_-_ridagene_factor_v_dk.pdf (Danish)
sdspy1210_-_ridagene_factor_v_ee.pdf (Estonian)
sdspy1210_-_ridagene_factor_v_fi.pdf (Finnish)
sdspy1210_-_ridagene_factor_v_gr.pdf (Greek)
sdspy1210_-_ridagene_factor_v_hr.pdf (Croatian)
sdspy1210_-_ridagene_factor_v_hu.pdf (Hungarian)
sdspy1210_-_ridagene_factor_v_lt.pdf (Lithuanian)
sdspy1210_-_ridagene_factor_v_lv.pdf (Latvian)
sdspy1210_-_ridagene_factor_v_nl.pdf (Dutch)
sdspy1210_-_ridagene_factor_v_no.pdf (Norwegian)
sdspy1210_-_ridagene_factor_v_pl.pdf (Polish)
sdspy1210_-_ridagene_factor_v_pt.pdf (Portuguese)
sdspy1210_-_ridagene_factor_v_ro.pdf (Romanian)
sdspy1210_-_ridagene_factor_v_se.pdf (Swedish)
sdspy1210_-_ridagene_factor_v_si.pdf (Slovenian)
sdspy1210_-_ridagene_factor_v_sk.pdf (Slovakian)
sdspy1210_-_ridagene_factor_v_tr.pdf (Turkish)
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