Intended use:
RIDASCREEN® GLM Monitoring is an enzyme linked immunoassay intended for the quantitative determination of golimumab (GLM, Simponi®) in human serum and plasma.
General information:
Golimumab (GLM) is a human monoclonal antibody and binds to both the soluble and transmembrane bioactive forms of human TNF-alpha, giving rise to stable high-affinity complexes thereby preventing the binding of TNF-alpha to its receptors. Golimumab has been approved for the treatment of various chronic immune-mediated inflammatory disorders in which TNF-alpha plays an important role, including rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis and ulcerative colitis (UC). Recent data on TDM have shown a positive relation between GLM trough serum concentrations and clinical outcomes in patients with RA3 and UC4. TDM may therefore be very instrumental to optimize treatment.
RIDASCREEN® GLM Monitoring uses a highly specific monoclonal antibody (MA-GOM171D8), which was isolated and characterized at the KU Leuven. It detects only golimumab; other anti-TNF drugs (like infliximab, adalimumab) do not interfere with the measurement.
Key features:
- CE-marked version of the ELISA tests of KU Leuven
- Highly specific antibodies
- Ready to use reagents
- Validated for use on automated ELISA systems, e.g. the Dynex DSX®
| Art. No. | G09047 |
|---|---|
| Test format | Microtiterplate with 96 wells (12 strips with 8 breakable wells each) |
| Incubation time | 1 h 40 min |
