Intended use:

For in vitro diagnostic use. RIDA®GENE Coronavirus is a multiplex real-time RT-PCR for the direct, qualitative detection and differentiation of coronaviruses (HKU1, NL63, 229E, OC43) and MERS from human nasal and throat swabs, throat washes, Sputum and BAL.

RIDA®GENE Coronavirus real-time RT-PCR is intended for use as an aid in the diagnosis of coronavirus infections.

General information:

Coronaviruses belong to the family of Coronaviridae and are single-stranded (ss) RNA viruses. Due to their high genetic variability, single virus species are able to overcome the art barrier and can infect different host species. Examples of such species transfers are infections with SARS-CoV (Sever Acute Respiratory Syndrome Coronavirus) which were responsible for the SARS pandemic 2002/2003 and the in 2012 newly occurring MERS-CoV (Middle-East Respiratory Syndrome Coronavirus).

SARS-CoV cause symptoms of an atypical pneumoniae and led to more than 1000 deaths during the pandemics in 2002/2003. It is suggested that the original reservoir are civets and bats. Even if the different transmission routes are not fully resolved, is the primary route of transmission via droplet infection. A transmission via smear infection or via the fecal-oral route can also not be excluded.

Until 2015, there were 1100 confirmed cases of MERS-CoV and more than 420 MERS-CoV-associated deaths. The majority of cases were reported on the Arabic peninsula. Also for MERS the original reservoir is not clearly identified yet, it is however suggested that the primary host of transmission are dromedaries.

Besides SARS-CoV and MERS-CoV the other human pathogenic coronaviruses are HKU1, NL63, 229E, OC43 which can cause mild respiratory infections but also severe acute respiratory syndromes. Although all four coronaviruses appear globally, they are reported in different regions at different times worldwide.

The human Coronavirus 229E (HCoV-229E) belongs to the genus Alphacoronavirus and together with human coronavirus PC43 (HCoV-OC43, genus: Betacoronavirus) often responsible for coughs and sneezes.

Further Betacoronviruses are SARS-CoV, MERS-CoV and HKU1. The latter one was diagnosed 2005 in a hospitalized patient with akute respiratory syndrome and pneumoniae in China.

Infections with the human Coronavirus NL63 (HCoV-NL63) are similar to Parainfluenza infections. The virus was detected in 2003 in the Netherlands in a child with bronchiolitis and was ever since primarily detected in young children and immunocompromised patients with acute respiratory syndrome.

Art. No. PG6805
Test format real-time RT-PCR with 100 reactions
Shelf life 24 months after production
Sensitivity Analytical Sensitivity : ≥ 50 RNA copies per reaction
English (English) (German) (French) (Italian) (Spanish)
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