Intended use:

For in vitro diagnostic use. RIDA®GENE Flu & RSV is a multiplex real-time RT-PCR for the direct, qualitative detection and differentiation of influenza viruses (Influenza A, Influenza B and RSV) from human nasal and throat swabs. RIDA®GENE Flu & RSV real-time RT-PCR is intended for use as an aid in the diagnosis of influenza and RSV infection.

General Information:

Influenza, also called flu, is the most common respiratory infectious disease which is caused by influenza viruses. Influenza viruses are RNA viruses belonging to the family of Orthomyxoviridae. They are divided into the subtypes A, B and C. Characteristic for influenza viruses is their diversity, their high mutational variation (antigenic drift) of the surface antigens, hemagglutinin (HA) and neuraminidase (NA) and reassortement of a human and non-human influenza strain (antigenic shift) leading to new influenza subtypes. Influenza types A and B cause the annually occuring influenza epidemics whereas infection with influenza C viruses cause milder disease. Worldwide, 3 – 5 million people are infected with influenza and approximately    250,000 – 500,000 die from this disease each year. The annual influenza epidemics cause serious public health and economic problems.In the U.S., influenza causes more than 200,000 hospitalizations and more than 36,000 deaths annually. In the season 2010/2011 more than 41,000 cases of influenza were reported in Germany. The transmission of influenza viruses occurs by droplets and aerosols. The incubation period is 1 – 4 days. Clinical symptoms are mainly severe diseases of the respiratory tract with high fever and cough. The onset of symptoms is characteristically abrupt (sudden onset).

Respiratory syncitial viruses (RSV) belong to the family of Paramyxoviridae and are enveloped single-stranded RNA viruses. There are two groups of RSV, group A and group B, whereas RSV A is most dominant in most years. RSV is spread worldwide and can lead to an infection of the upper and lower respiratory tract at every age. RSV is transmitted via smear or airborne transfection and patients show symptoms of rhinitis, cold, cough, acute bronchitis and also inflammation of the middle ear. An acute presentation may occur during the presence of a bacterial super infection and, worldwide, around 600 000 people die yearly from either direct or indirect infection with RSV.Infants and small children often show an acute presentation which requires hospitalization. Here, symptoms such as fever, cold and tachypnoe occur. 50 – 70 % of infants and small children have a RSV infection in at the age of one, whereas almost 100 % had a RSV infection after the age of two.

Art. No. PG0545
Test format real-time RT-PCR with 100 reactions
Shelf life 24 months after production
Sensitivity Analytical Sensitivity : ≥ 50 RNA copies per reaction
English (German) (English) (French) (Italian) (Spanish)
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