Intended use:

For in vitro diagnostic use. RIDA®GENE PVL is a real-time PCR for the direct, qualitative detection of the PVL-gene (Panton-Valentine leukocidin) from cultures.

RIDA®GENE PVL real-time PCR is intended for use as an aid in diagnosis of (skin- / soft tissue-) infections caused by PVL.

General information:

Staphylococcus aureus is a normal commensal of the skin and mucous membranes of humans that can be detected in 30% of the general population (asymptomatic carriers). Strains of Staphylococcus aureus which have developed antibiotic resistance methicillin and narrow-spectrum ß-lactamase resistant penicillin antibiotics are called MRSA (Methicillin-resistant Staphylococcus aureus). Staphylococcus aureus is a major cause of nosocomial infections in hospitals and healthcare settings.Since the mid-1990s the number of infections in the population increased with no previously history of medical facilitiy contact. This increase in infections in the population is caused by Staphylococcus aureus strains that carry the virulence factor Panton-Valentine leukocidin.

PVL can be produced by methicillin-sensitive Staphylocoocus aureus strains (MSSA) as well as and methicillin-resistant Staphylocoocus aureus strains (MRSA). MRSA strains that carry the virulence factor PVL are called CA-MRSA.  Panton-Valentine leukocidin (PVL) is a bicomponent, poreforming cytotoxin encoded by the lukF-PV and lukS-PV genes. The cytotoxin of PVL lysis macrophages as well as neutrophil granulocytes and contributes to tissue necrosis. The clinical manifestion of PVL-positive Staphylococcus aureus strains are skin and soft tissue infections, particularly recurrent invasive abscesses. Rarely necrotizing pneumonia develops with a mortality rate of up to 75%. Risk groups for transmission CA-MRSA or  PVL-MSSA are for example families, persons performing close contact sports, persons from educational settings, prisoners and military personnel. In the recent years infections with PVL-MSSA and PVL-MRSA increased worldwide.

Specifications
Art. No. PG0645
Test format real-time PCR with 100 reactions
Shelf life 24 months after production
Sensitivity Analytical Sensitivity: ≥ 10 DNA copies per reaction
Files
InstructionsGerman
English
SDSPG0645_german.zip (German)
PG0645_english.zip (English)
PG0645_french.zip (French)
PG0645_italian.zip (Italian)
PG0645_spanish.zip (Spanish)
Similar products
SeraSpot® Anti-Parvovirus-6 IgG / SeraSpot® Anti-Parvovirus-5 IgM
SeraSpot® Anti-Parvovirus-6...
The SeraSpot® Anti-Parvovirus-6 IgG / SeraSpot® Anti-Parvovirus-5 IgM test is an in vitro diagnostic device (spotimmunoassay, SIA) for the detecti...
SeraSpot® Anti-EBV-4 IgG / SeraSpot® Anti-EBV-3 IgM
SeraSpot® Anti-EBV-4 IgG / ...
The SeraSpot® Anti-EBV-4 IgG / SeraSpot® Anti-EBV-3 IgM test is an in vitro diagnostic device (spotimmunoassay, SIA) for the detection of EBV-speci...
RIDASCREEN® Hantavirus Puumala IgG, IgM
RIDASCREEN® Hantavirus Puum...
For in vitro diagnostic use. The RIDASCREEN® Hantavirus Puumala virus tests are enzyme immunoassays for the quantitative detection of IgG or IgM an...

Start typing and press Enter to search

pg0845_ridagene-clostridium-difficile-lc2ridaquick-clostridium-difficile-gdh