For in vitro diagnostic use. RIDA®GENE Akkermansia muciniphila is a multiplex real-time PCR for the direct qualitative and quantitative detection of Akkermansia muciniphila DNA from human stool samples.
It is becoming more and more apparent that the composition of the gut microbiota affects human health and is associated with different diseases conditions including inflammatory bowel diseases (IBD’s), metabolic syndrome and obesity. Currently, it is not yet known whether alterations in the microbiota are a cause or an effect of such diseases.
Akkermansia muciniphila (A. muciniphila) is a gram-negative, mucin-degrading bacterium and is naturally present in the human microbiota. It represents 3-5 % of the bacterial population in a healthy person. A. muciniphila is located in special areas of the human mucosa and can be detected in stool samples of infants from the age of less than beeing one month. Afterwards, the quantity of A. muciniphila increases with age. In elderly people numbers of A. muciniphila are significantly reduced. A. muciniphila can be partially associated with diabetes, adiposity and Inflammatory Bowel Disease (IBD).
|Test format||real-time PCR with 100 reactions|
|Shelf life||24 month after production|
|Sensitivity||≥ 10 DNA copies per reaction|