RIDA®GENE Gut Balance

Intended use:

For in vitro diagnostic use. RIDA^®GENE Gut Balance is a multiplex real-time PCR for the direct qualitative and quantitative detection of Bacteroides– and Cluster XIVa DNA from human stool samples.

General information:

90% of the normal human gut flora is populated by two phylogenetic groups which exist in a symbiotic balance. Bacteroides are anaerobic, gram-negative bacteria which are part of the normal gut flora of the intestinal tract. In the large intestine, approximately 10¹¹ Bacteroides/g stool exist and are therefore the dominant bacteria in terms of numbers. The second phylogenetic group is the firmicutes. Clostridium Cluster XIVa are a class of firmicutes to which, besides others, Eubacterium spp. and roseburia spp. belong.

Different sources associate a disbalance of the composition of the gut flora (dysbiosis) with obesity. Here, a decreased number of Bacteroides corresponds to presence of obesity whereas at the same time an increasing number of Eubacterium rectale was detected in patients with obesity.