Intended use:

For in vitro diagnostic use. RIDA®GENE Enterovirus is a real-time RT-PCR for the direct, qualitative detection of Enterovirus from human stool samples and cerebrospinal fluid (CSF).

RIDA®GENE Enterovirus real-time RT-PCR is intended for use as an aid in diagnosis of infections caused by enteroviruses (poliovirus, echovirus, coxsackievirus, human enterovirus 70/71).

General information:

Human enteroviruses belong to the family of Picornaviridae and according to a new classification are divided into five species. These are Poliovirus, human enterovirus A, human enterovirus B, human enterovirus C and human enterovirus D and until today over 90 enterovirus serotypes have been described.Coxsackie virus A belongs to the species of human enterovirus A and C and coxsackie virus B as well as Echovirus belong to human enterovirus B. Enteroviruses mainly infect infants and small children and are transmitted via the fecal/oral route but also sometimes by droplet infection and contaminated water. Most enterovirus infections are asymptomatic or present with mild cold-like symptoms. Though, due to the multitude of enterovirus species the clinical presentation in severe symptomatic diseases is of broad variety. Severe enterovirus infections are poliomyelitis, Hand, Foot, and Mouth disease, meningitis and myocarditis.

Polioviruses are single-stranded RNA (ss-RNA) viruses and before their partial eradication were distributed worldwide. Besides mild symptoms such as fever and cough, poliovirus can also cause poliomyelitis. However, the last case of poliomyelitis was reported in 1991 in Peru.

In 1984, coxsackie virus A and B were first reported and named after their place of detection in Coxsackie, New York. Coxsackie viruses are present worldwide and both stems can cause the so called “summer diarrhea”. In the US, the Hand, Foot, and Mouth disease is mostly caused by coxsackie virus A16 whereas other severe coxsackie infections lead to conjunctivitis and myocarditis.Besides coxsackie virus, also an infection with human enterovirus 70 can lead to an acute conjuncitivitis.

Human enterovirus 71 causes Hand, Foot, and Mouth disease, however mostly infections with human enterovirus 71 are asymptomatic. This single-stranded RNA (ss-RNA) virus is distributed worldwide and most often occurs in later summer and fall.

Echovirus is highly infectious and occurs mostly in children. Echovirus can, besides others, lead to aseptic meningitis whereby echovirus 30 is the most common meningitis causing serotype in Europe, America and Asia.

Art. No. PG4705
Test format real-time RT-PCR with 100 reactions
Shelf life 24 months after production
Sensitivity Analytical Sensitivity : ≥ 50 RNA copies per reaction
English (German) (English) (French) (Italian) (Spanish)
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